| # | Player | Team | Qtr | Yards | Game |
|---|---|---|---|---|---|
| 1 | Jonathan Taylor | IND | Q4 | 113 | wk 10 vs ATL |
| 2 | Bijan Robinson | ATL | Q2 | 101 | wk 17 vs LA |
| 3 | Derrick Henry | BAL | Q2 | 101 | wk 1 @ BUF |
| 4 | Bijan Robinson | ATL | Q2 | 98 | wk 6 vs BUF |
| 5 | Jonathan Taylor | IND | Q4 | 98 | wk 2 vs DEN |
| 6 | De'Von Achane | MIA | Q4 | 97 | wk 10 vs BUF |
| 7 | Jaylen Warren | PIT | Q4 | 90 | wk 16 @ DET |
| 8 | Javonte Williams | DAL | Q2 | 88 | wk 5 @ NYJ |
| 9 | Tony Pollard | TEN | Q1 | 87 | wk 14 @ CLE |
| 10 | Jahmyr Gibbs | DET | Q2 | 86 | wk 7 vs TB |
Weekly