| # | Player | Team | Games | Q1 rush yds | Per game | Best Q1 |
|---|---|---|---|---|---|---|
| 1 | De'Von Achane | MIA | 16 | 518 | 32.4 | 67 vs LAC (wk 6) |
| 2 | James Cook | BUF | 17 | 491 | 28.9 | 79 @ CAR (wk 8) |
| 3 | Derrick Henry | BAL | 17 | 444 | 26.1 | 79 @ PIT (wk 18) |
| 4 | Bijan Robinson | ATL | 17 | 395 | 23.2 | 54 @ MIN (wk 2) |
| 5 | Javonte Williams | DAL | 16 | 383 | 23.9 | 60 @ CHI (wk 3) |
| 6 | Kyren Williams | LA | 17 | 377 | 22.2 | 76 vs SEA (wk 11) |
| 7 | Jonathan Taylor | IND | 17 | 374 | 22.0 | 62 vs TEN (wk 8) |
| 8 | Tony Pollard | TEN | 17 | 373 | 21.9 | 87 @ CLE (wk 14) |
| 9 | Saquon Barkley | PHI | 16 | 368 | 23.0 | 82 vs NYG (wk 8) |
| 10 | Christian McCaffrey | SF | 17 | 305 | 17.9 | 61 vs CHI (wk 17) |
| 11 | Rhamondre Stevenson | NE | 14 | 304 | 21.7 | 67 vs MIA (wk 18) |
| 12 | Jahmyr Gibbs | DET | 17 | 277 | 16.3 | 32 @ KC (wk 6) |
| 13 | Chase Brown | CIN | 17 | 270 | 15.9 | 37 vs NE (wk 12) |
| 14 | D'Andre Swift | CHI | 16 | 269 | 16.8 | 43 @ PHI (wk 13) |
| 15 | Kenneth Walker III | SEA | 17 | 258 | 15.2 | 41 @ SF (wk 18) |
| 16 | Rico Dowdle | CAR | 17 | 256 | 15.1 | 34 vs NO (wk 10) |
| 17 | Ashton Jeanty | LV | 17 | 254 | 14.9 | 35 vs JAX (wk 9) |
| 18 | Jaylen Warren | PIT | 16 | 254 | 15.9 | 48 vs CIN (wk 11) |
| 19 | Josh Jacobs | GB | 15 | 249 | 16.6 | 48 @ DET (wk 13) |
| 20 | Breece Hall | NYJ | 16 | 241 | 15.1 | 42 vs DAL (wk 5) |
| 21 | Quinshon Judkins | CLE | 14 | 231 | 16.5 | 48 vs MIN (wk 5) |
| 22 | Travis Etienne | JAX | 17 | 222 | 13.1 | 51 @ ARI (wk 12) |
| 23 | Kyle Monangai | CHI | 17 | 199 | 11.7 | 63 @ CIN (wk 9) |
| 24 | TreVeyon Henderson | NE | 17 | 194 | 11.4 | 30 vs CLE (wk 8) |
| 25 | Bucky Irving | TB | 10 | 186 | 18.6 | 29 @ CAR (wk 16) |
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