| # | Player | Team | Qtr | Yards | Game |
|---|---|---|---|---|---|
| 1 | Josh Allen | BUF | Q4 | 251 | wk 1 vs BAL |
| 2 | Joe Flacco | CIN | Q4 | 226 | wk 9 vs CHI |
| 3 | Sam Darnold | SEA | Q2 | 215 | wk 9 @ WAS |
| 4 | Jared Goff | DET | Q4 | 200 | wk 16 vs PIT |
| 5 | Cam Ward | TEN | Q4 | 193 | wk 5 @ ARI |
| 6 | Justin Herbert | LAC | Q3 | 193 | wk 7 vs IND |
| 7 | Tua Tagovailoa | MIA | Q4 | 188 | wk 15 @ PIT |
| 8 | Daniel Jones | IND | Q4 | 185 | wk 9 @ PIT |
| 9 | Josh Allen | BUF | Q4 | 185 | wk 10 @ MIA |
| 10 | Bo Nix | DEN | Q4 | 174 | wk 7 vs NYG |
Weekly