| # | Player | Team | Games | Q1 pass yds | Per game | Best Q1 |
|---|---|---|---|---|---|---|
| 1 | Jared Goff | DET | 17 | 1115 | 65.6 | 137 vs TB (wk 7) |
| 2 | Matthew Stafford | LA | 17 | 1086 | 63.9 | 123 @ SEA (wk 16) |
| 3 | Trevor Lawrence | JAX | 17 | 1054 | 62.0 | 119 @ CIN (wk 2) |
| 4 | Dak Prescott | DAL | 17 | 932 | 54.8 | 117 vs WAS (wk 7) |
| 5 | C.J. Stroud | HOU | 14 | 931 | 66.5 | 151 @ LAC (wk 17) |
| 6 | Daniel Jones | IND | 13 | 913 | 70.2 | 139 vs DEN (wk 2) |
| 7 | Jordan Love | GB | 15 | 910 | 60.7 | 131 @ DAL (wk 4) |
| 8 | Caleb Williams | CHI | 17 | 890 | 52.4 | 135 vs DAL (wk 3) |
| 9 | Drake Maye | NE | 17 | 883 | 51.9 | 113 @ NYJ (wk 17) |
| 10 | Sam Darnold | SEA | 17 | 838 | 49.3 | 95 vs ARI (wk 10) |
| 11 | Justin Herbert | LAC | 16 | 787 | 49.2 | 118 vs KC (wk 1) |
| 12 | Cam Ward | TEN | 17 | 746 | 43.9 | 101 vs NE (wk 7) |
| 13 | Geno Smith | LV | 15 | 729 | 48.6 | 109 @ NE (wk 1) |
| 14 | Aaron Rodgers | PIT | 16 | 724 | 45.2 | 93 @ NYJ (wk 1) |
| 15 | Baker Mayfield | TB | 17 | 703 | 41.4 | 84 vs NO (wk 14) |
| 16 | Bo Nix | DEN | 17 | 682 | 40.1 | 101 @ NYJ (wk 6) |
| 17 | Josh Allen | BUF | 16 | 680 | 42.5 | 103 vs NO (wk 4) |
| 18 | Bryce Young | CAR | 16 | 643 | 40.2 | 82 @ ATL (wk 11) |
| 19 | Jalen Hurts | PHI | 16 | 626 | 39.1 | 90 @ DAL (wk 12) |
| 20 | Patrick Mahomes | KC | 14 | 624 | 44.6 | 113 vs LV (wk 7) |
| 21 | Jacoby Brissett | ARI | 14 | 609 | 43.5 | 76 vs LA (wk 14) |
| 22 | Tua Tagovailoa | MIA | 14 | 600 | 42.9 | 103 @ NYJ (wk 14) |
| 23 | Jaxson Dart | NYG | 14 | 541 | 38.6 | 101 vs PHI (wk 6) |
| 24 | Lamar Jackson | BAL | 13 | 523 | 40.2 | 69 vs NE (wk 16) |
| 25 | Brock Purdy | SF | 9 | 519 | 57.7 | 93 vs CHI (wk 17) |
Jared Goff (DET), with 1115 passing yards in the first quarter — 65.6 per game across 17 games.
C.J. Stroud: 151 passing yards in Q1 at LAC in week 17.
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