| # | Player | Team | Games | Q4 rush yds | Per game | Best Q4 |
|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | IND | 17 | 416 | 24.5 | 113 vs ATL (wk 10) |
| 2 | Kyren Williams | LA | 17 | 384 | 22.6 | 69 @ ATL (wk 17) |
| 3 | De'Von Achane | MIA | 16 | 348 | 21.8 | 97 vs BUF (wk 10) |
| 4 | Derrick Henry | BAL | 17 | 326 | 19.2 | 70 @ GB (wk 17) |
| 5 | Breece Hall | NYJ | 16 | 289 | 18.1 | 58 vs NE (wk 17) |
| 6 | Travis Etienne | JAX | 17 | 287 | 16.9 | 41 vs CAR (wk 1) |
| 7 | D'Andre Swift | CHI | 16 | 278 | 17.4 | 47 @ MIN (wk 11) |
| 8 | Rico Dowdle | CAR | 17 | 264 | 15.5 | 74 vs MIA (wk 5) |
| 9 | Josh Jacobs | GB | 15 | 261 | 17.4 | 42 @ DAL (wk 4) |
| 10 | TreVeyon Henderson | NE | 17 | 260 | 15.3 | 70 vs BUF (wk 15) |
| 11 | Jahmyr Gibbs | DET | 17 | 252 | 14.8 | 53 vs NYG (wk 12) |
| 12 | Jordan Mason | MIN | 16 | 246 | 15.4 | 53 @ CHI (wk 1) |
| 13 | Jaylen Warren | PIT | 16 | 244 | 15.2 | 90 @ DET (wk 16) |
| 14 | Blake Corum | LA | 17 | 242 | 14.2 | 48 @ ARI (wk 14) |
| 15 | Saquon Barkley | PHI | 16 | 240 | 15.0 | 76 @ WAS (wk 16) |
| 16 | Tony Pollard | TEN | 17 | 240 | 14.1 | 48 vs KC (wk 16) |
| 17 | J.K. Dobbins | DEN | 10 | 237 | 23.7 | 47 vs CIN (wk 4) |
| 18 | James Cook | BUF | 17 | 231 | 13.6 | 41 @ NE (wk 15) |
| 19 | Josh Allen | BUF | 16 | 231 | 14.4 | 55 vs CIN (wk 14) |
| 20 | Christian McCaffrey | SF | 17 | 227 | 13.4 | 32 @ IND (wk 16) |
| 21 | Kenneth Walker III | SEA | 17 | 225 | 13.2 | 42 @ PIT (wk 2) |
| 22 | Javonte Williams | DAL | 16 | 222 | 13.9 | 29 vs GB (wk 4) |
| 23 | Tyler Allgeier | ATL | 17 | 220 | 12.9 | 50 @ MIN (wk 2) |
| 24 | Quinshon Judkins | CLE | 14 | 216 | 15.4 | 62 vs GB (wk 3) |
| 25 | Jacory Croskey-Merritt | WAS | 17 | 212 | 12.5 | 44 vs NYG (wk 1) |
Jonathan Taylor (IND), with 416 rushing yards in the fourth quarter — 24.5 per game across 17 games.
Jonathan Taylor: 113 rushing yards in Q4 vs ATL in week 10.
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