| # | Player | Team | Games | Q2 rece yds | Per game | Best Q2 |
|---|---|---|---|---|---|---|
| 1 | Jaxon Smith-Njigba | SEA | 17 | 564 | 33.2 | 93 @ JAX (wk 6) |
| 2 | Puka Nacua | LA | 16 | 499 | 31.2 | 94 vs IND (wk 4) |
| 3 | Nico Collins | HOU | 15 | 453 | 30.2 | 89 vs JAX (wk 10) |
| 4 | Ja'Marr Chase | CIN | 16 | 443 | 27.7 | 71 @ BAL (wk 13) |
| 5 | Amon-Ra St. Brown | DET | 17 | 432 | 25.4 | 94 @ LA (wk 15) |
| 6 | Justin Jefferson | MIN | 17 | 409 | 24.1 | 59 @ PIT (wk 4) |
| 7 | Trey McBride | ARI | 17 | 406 | 23.9 | 59 vs CAR (wk 2) |
| 8 | Courtland Sutton | DEN | 17 | 393 | 23.1 | 96 @ LAC (wk 3) |
| 9 | George Pickens | DAL | 17 | 381 | 22.4 | 68 vs GB (wk 4) |
| 10 | Chris Olave | NO | 16 | 380 | 23.8 | 85 @ CAR (wk 10) |
| 11 | Jaylen Waddle | MIA | 16 | 333 | 20.8 | 82 vs LAC (wk 6) |
| 12 | Tetairoa McMillan | CAR | 17 | 333 | 19.6 | 51 vs BUF (wk 8) |
| 13 | Ladd McConkey | LAC | 16 | 328 | 20.5 | 58 vs MIN (wk 8) |
| 14 | Jerry Jeudy | CLE | 17 | 305 | 17.9 | 74 vs TEN (wk 14) |
| 15 | Quentin Johnston | LAC | 13 | 304 | 23.4 | 90 vs HOU (wk 17) |
| 16 | DeVonta Smith | PHI | 17 | 299 | 17.6 | 66 vs DEN (wk 5) |
| 17 | Hunter Henry | NE | 17 | 295 | 17.4 | 57 @ CIN (wk 12) |
| 18 | Michael Pittman | IND | 17 | 286 | 16.8 | 61 vs TEN (wk 8) |
| 19 | Zay Flowers | BAL | 17 | 283 | 16.6 | 54 @ CIN (wk 15) |
| 20 | CeeDee Lamb | DAL | 13 | 282 | 21.7 | 89 @ DET (wk 14) |
| 21 | Kyle Pitts | ATL | 17 | 278 | 16.4 | 72 @ TB (wk 15) |
| 22 | Stefon Diggs | NE | 17 | 277 | 16.3 | 58 @ NYJ (wk 17) |
| 23 | Alec Pierce | IND | 15 | 272 | 18.1 | 71 @ LAC (wk 7) |
| 24 | George Kittle | SF | 11 | 269 | 24.5 | 53 @ CLE (wk 13) |
| 25 | Drake London | ATL | 12 | 268 | 22.3 | 83 vs BUF (wk 6) |
Jaxon Smith-Njigba (SEA), with 564 receiving yards in the second quarter — 33.2 per game across 17 games.
Courtland Sutton: 96 receiving yards in Q2 at LAC in week 3.
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