| Player | Pos | Stat | Q1 yds/gm | G |
|---|---|---|---|---|
| Brock Purdy | QB | passing | 57.7 | 9 |
| Mac Jones | QB | passing | 31.3 | 11 |
| Christian McCaffrey | RB | rushing | 17.9 | 17 |
| Brian Robinson | RB | rushing | 5.0 | 16 |
| Kyle Juszczyk | RB | rushing | 0.0 | 15 |
| Ricky Pearsall | WR | receiving | 12.2 | 9 |
| Demarcus Robinson | WR | receiving | 7.8 | 14 |
| Jauan Jennings | WR | receiving | 6.7 | 15 |
| Kendrick Bourne | WR | receiving | 5.4 | 14 |
| George Kittle | TE | receiving | 13.4 | 11 |
| Jake Tonges | TE | receiving | 5.6 | 9 |
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