| Final | Line | ATS | Total |
|---|---|---|---|
| THURSDAY · OCT 2 | |||
| SF 26 @ LA 23 | LA -8.5 | SF covered — outright upset | Over 43.5 |
| SUNDAY · OCT 5 | |||
| MIN 21 @ CLE 17 | MIN -3.5 | MIN covered | Over 35.5 |
| HOU 44 @ BAL 10 | HOU -2.5 | HOU covered | Over 41.5 |
| MIA 24 @ CAR 27 | MIA -1.5 | CAR covered — outright upset | Over 44.5 |
| LV 6 @ IND 40 | IND -7 | IND covered | Under 46.5 |
| NYG 14 @ NO 26 | NO -1.5 | NO covered | Under 41.5 |
| DAL 37 @ NYJ 22 | NYJ -1.5 | DAL covered — outright upset | Over 48.5 |
| DEN 21 @ PHI 17 | PHI -3.5 | DEN covered — outright upset | Under 44.5 |
| TEN 22 @ ARI 21 | ARI -7.5 | TEN covered — outright upset | Over 41.5 |
| TB 38 @ SEA 35 | SEA -3.5 | TB covered — outright upset | Over 44.5 |
| DET 37 @ CIN 24 | DET -10.5 | DET covered | Over 49.5 |
| WAS 27 @ LAC 10 | LAC -2.5 | WAS covered — outright upset | Under 47.5 |
| NE 23 @ BUF 20 | BUF -7.5 | NE covered — outright upset | Under 49.5 |
| MONDAY · OCT 6 | |||
| KC 28 @ JAX 31 | KC -3.5 | JAX covered — outright upset | Over 45.5 |
Favorites went 5–9 against the closing spread in week 5 of 2025.
San Francisco 49ers beating Los Angeles Rams outright as a +8.5 underdog.
Overs went 9–5 across the week's games.
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