| # | Player | Team | Games | Q4 pass yds | Per game | Best Q4 |
|---|---|---|---|---|---|---|
| 1 | Josh Allen | BUF | 16 | 1216 | 76.0 | 251 vs BAL (wk 1) |
| 2 | Dak Prescott | DAL | 17 | 1178 | 69.3 | 150 @ DET (wk 14) |
| 3 | Bo Nix | DEN | 17 | 1130 | 66.5 | 174 vs NYG (wk 7) |
| 4 | Cam Ward | TEN | 17 | 1101 | 64.8 | 193 @ ARI (wk 5) |
| 5 | Jared Goff | DET | 17 | 1100 | 64.7 | 200 vs PIT (wk 16) |
| 6 | Caleb Williams | CHI | 17 | 1096 | 64.5 | 137 @ BAL (wk 8) |
| 7 | Baker Mayfield | TB | 17 | 1059 | 62.3 | 172 @ MIA (wk 17) |
| 8 | Matthew Stafford | LA | 17 | 1024 | 60.2 | 172 vs IND (wk 4) |
| 9 | Jacoby Brissett | ARI | 14 | 969 | 69.2 | 141 vs SF (wk 11) |
| 10 | Tyler Shough | NO | 11 | 931 | 84.6 | 164 @ TEN (wk 17) |
| 11 | Jalen Hurts | PHI | 16 | 907 | 56.7 | 123 vs CHI (wk 13) |
| 12 | Patrick Mahomes | KC | 14 | 903 | 64.5 | 123 vs IND (wk 12) |
| 13 | Geno Smith | LV | 15 | 894 | 59.6 | 165 @ WAS (wk 3) |
| 14 | Joe Flacco | CIN | 13 | 894 | 68.8 | 226 vs CHI (wk 9) |
| 15 | Sam Darnold | SEA | 17 | 890 | 52.4 | 132 @ LA (wk 11) |
| 16 | Aaron Rodgers | PIT | 16 | 878 | 54.9 | 133 vs BAL (wk 18) |
| 17 | Bryce Young | CAR | 16 | 876 | 54.8 | 169 @ ARI (wk 2) |
| 18 | Drake Maye | NE | 17 | 824 | 48.5 | 139 @ BAL (wk 16) |
| 19 | Tua Tagovailoa | MIA | 14 | 787 | 56.2 | 188 @ PIT (wk 15) |
| 20 | Justin Herbert | LAC | 16 | 785 | 49.1 | 123 vs DEN (wk 3) |
| 21 | Trevor Lawrence | JAX | 17 | 720 | 42.4 | 111 vs LA (wk 7) |
| 22 | Jordan Love | GB | 15 | 714 | 47.6 | 93 vs PHI (wk 10) |
| 23 | Lamar Jackson | BAL | 13 | 701 | 53.9 | 171 @ PIT (wk 18) |
| 24 | C.J. Stroud | HOU | 14 | 645 | 46.1 | 126 @ JAX (wk 3) |
| 25 | Mac Jones | SF | 11 | 579 | 52.6 | 105 vs ARI (wk 3) |
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