| # | Player | Team | Games | Q3 rush yds | Per game | Best Q3 |
|---|---|---|---|---|---|---|
| 1 | Derrick Henry | BAL | 17 | 468 | 27.5 | 83 @ CIN (wk 15) |
| 2 | James Cook | BUF | 17 | 457 | 26.9 | 63 @ CAR (wk 8) |
| 3 | Jonathan Taylor | IND | 17 | 456 | 26.8 | 81 vs TEN (wk 8) |
| 4 | Kenneth Walker III | SEA | 17 | 398 | 23.4 | 56 vs LA (wk 16) |
| 5 | Christian McCaffrey | SF | 17 | 334 | 19.6 | 32 @ NYG (wk 9) |
| 6 | Bijan Robinson | ATL | 17 | 315 | 18.5 | 47 @ MIN (wk 2) |
| 7 | J.K. Dobbins | DEN | 10 | 306 | 30.6 | 83 @ LAC (wk 3) |
| 8 | Javonte Williams | DAL | 16 | 302 | 18.9 | 58 vs MIN (wk 15) |
| 9 | Rico Dowdle | CAR | 17 | 293 | 17.2 | 59 vs MIA (wk 5) |
| 10 | Jahmyr Gibbs | DET | 17 | 276 | 16.2 | 40 vs CLE (wk 4) |
| 11 | D'Andre Swift | CHI | 16 | 273 | 17.1 | 53 vs CLE (wk 15) |
| 12 | Saquon Barkley | PHI | 16 | 268 | 16.8 | 44 vs LV (wk 15) |
| 13 | Breece Hall | NYJ | 16 | 261 | 16.3 | 59 @ CIN (wk 8) |
| 14 | Jaylen Warren | PIT | 16 | 260 | 16.2 | 44 @ DET (wk 16) |
| 15 | Tyrone Tracy Jr. | NYG | 15 | 260 | 17.3 | 41 @ DEN (wk 7) |
| 16 | Chase Brown | CIN | 17 | 256 | 15.1 | 47 @ PIT (wk 11) |
| 17 | David Montgomery | DET | 17 | 253 | 14.9 | 83 @ BAL (wk 3) |
| 18 | Jacory Croskey-Merritt | WAS | 17 | 253 | 14.9 | 83 vs DAL (wk 17) |
| 19 | Kimani Vidal | LAC | 12 | 244 | 20.3 | 74 vs LV (wk 13) |
| 20 | Tony Pollard | TEN | 17 | 237 | 13.9 | 55 @ CLE (wk 14) |
| 21 | Josh Jacobs | GB | 15 | 232 | 15.5 | 37 @ DEN (wk 15) |
| 22 | Travis Etienne | JAX | 17 | 222 | 13.1 | 32 @ LV (wk 9) |
| 23 | TreVeyon Henderson | NE | 17 | 221 | 13.0 | 61 @ TB (wk 10) |
| 24 | Ashton Jeanty | LV | 17 | 220 | 12.9 | 31 vs TEN (wk 6) |
| 25 | Jordan Mason | MIN | 16 | 216 | 13.5 | 75 vs CIN (wk 3) |
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