| # | Player | Team | Games | Q2 rush yds | Per game | Best Q2 |
|---|---|---|---|---|---|---|
| 1 | Bijan Robinson | ATL | 17 | 581 | 34.2 | 101 vs LA (wk 17) |
| 2 | James Cook | BUF | 17 | 442 | 26.0 | 74 @ CAR (wk 8) |
| 3 | Derrick Henry | BAL | 17 | 357 | 21.0 | 101 @ BUF (wk 1) |
| 4 | Travis Etienne | JAX | 17 | 356 | 20.9 | 85 vs CAR (wk 1) |
| 5 | Jahmyr Gibbs | DET | 17 | 349 | 20.5 | 86 vs TB (wk 7) |
| 6 | Chase Brown | CIN | 17 | 337 | 19.8 | 68 vs PIT (wk 7) |
| 7 | Christian McCaffrey | SF | 17 | 336 | 19.8 | 68 vs ATL (wk 7) |
| 8 | Ashton Jeanty | LV | 17 | 331 | 19.5 | 67 vs CHI (wk 4) |
| 9 | De'Von Achane | MIA | 16 | 316 | 19.8 | 44 vs TB (wk 17) |
| 10 | Jonathan Taylor | IND | 17 | 302 | 17.8 | 54 vs ARI (wk 6) |
| 11 | Kyren Williams | LA | 17 | 276 | 16.2 | 42 @ PHI (wk 3) |
| 12 | Breece Hall | NYJ | 16 | 274 | 17.1 | 38 @ MIA (wk 4) |
| 13 | D'Andre Swift | CHI | 16 | 260 | 16.2 | 45 @ PHI (wk 13) |
| 14 | Saquon Barkley | PHI | 16 | 260 | 16.2 | 39 @ WAS (wk 16) |
| 15 | Rico Dowdle | CAR | 17 | 257 | 15.1 | 68 vs MIA (wk 5) |
| 16 | Javonte Williams | DAL | 16 | 256 | 16.0 | 88 @ NYJ (wk 5) |
| 17 | TreVeyon Henderson | NE | 17 | 236 | 13.9 | 61 vs BUF (wk 15) |
| 18 | Tony Pollard | TEN | 17 | 232 | 13.6 | 43 vs LA (wk 2) |
| 19 | Woody Marks | HOU | 16 | 231 | 14.4 | 40 vs IND (wk 18) |
| 20 | Rachaad White | TB | 17 | 211 | 12.4 | 45 @ CAR (wk 16) |
| 21 | David Montgomery | DET | 17 | 205 | 12.1 | 35 vs DAL (wk 14) |
| 22 | Jaylen Warren | PIT | 16 | 200 | 12.5 | 40 vs GB (wk 8) |
| 23 | Kareem Hunt | KC | 17 | 200 | 11.8 | 33 @ JAX (wk 5) |
| 24 | Zach Charbonnet | SEA | 16 | 196 | 12.2 | 26 vs MIN (wk 13) |
| 25 | Jacory Croskey-Merritt | WAS | 17 | 194 | 11.4 | 43 @ NYG (wk 15) |
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