| # | Player | Team | Games | Q2 pass yds | Per game | Best Q2 |
|---|---|---|---|---|---|---|
| 1 | Drake Maye | NE | 17 | 1591 | 93.6 | 142 @ BAL (wk 16) |
| 2 | Dak Prescott | DAL | 17 | 1418 | 83.4 | 143 vs PHI (wk 12) |
| 3 | Matthew Stafford | LA | 17 | 1286 | 75.6 | 141 @ ARI (wk 14) |
| 4 | Jared Goff | DET | 17 | 1284 | 75.5 | 141 @ LA (wk 15) |
| 5 | Justin Herbert | LAC | 16 | 1257 | 78.6 | 119 @ NYG (wk 4) |
| 6 | Bo Nix | DEN | 17 | 1235 | 72.6 | 174 vs CIN (wk 4) |
| 7 | Sam Darnold | SEA | 17 | 1208 | 71.1 | 215 @ WAS (wk 9) |
| 8 | Trevor Lawrence | JAX | 17 | 1081 | 63.6 | 121 vs TEN (wk 18) |
| 9 | Jordan Love | GB | 15 | 999 | 66.6 | 120 @ DEN (wk 15) |
| 10 | Patrick Mahomes | KC | 14 | 989 | 70.6 | 104 @ BUF (wk 9) |
| 11 | Aaron Rodgers | PIT | 16 | 953 | 59.6 | 103 @ DET (wk 16) |
| 12 | Caleb Williams | CHI | 17 | 943 | 55.5 | 107 vs CLE (wk 15) |
| 13 | Baker Mayfield | TB | 17 | 938 | 55.2 | 112 vs SF (wk 6) |
| 14 | C.J. Stroud | HOU | 14 | 931 | 66.5 | 133 vs SF (wk 8) |
| 15 | Jacoby Brissett | ARI | 14 | 906 | 64.7 | 107 vs JAX (wk 12) |
| 16 | Jalen Hurts | PHI | 16 | 888 | 55.5 | 97 @ TB (wk 4) |
| 17 | Daniel Jones | IND | 13 | 878 | 67.5 | 142 @ LAC (wk 7) |
| 18 | Josh Allen | BUF | 16 | 829 | 51.8 | 133 vs TB (wk 11) |
| 19 | Cam Ward | TEN | 17 | 804 | 47.3 | 97 vs NO (wk 17) |
| 20 | Tua Tagovailoa | MIA | 14 | 759 | 54.2 | 111 vs LAC (wk 6) |
| 21 | Joe Flacco | CIN | 13 | 707 | 54.4 | 154 vs CHI (wk 9) |
| 22 | Mac Jones | SF | 11 | 705 | 64.1 | 138 @ TB (wk 6) |
| 23 | Jaxson Dart | NYG | 14 | 689 | 49.2 | 141 @ CHI (wk 10) |
| 24 | Geno Smith | LV | 15 | 678 | 45.2 | 104 vs JAX (wk 9) |
| 25 | Bryce Young | CAR | 16 | 668 | 41.8 | 85 vs TB (wk 16) |
Drake Maye (NE), with 1591 passing yards in the second quarter — 93.6 per game across 17 games.
Sam Darnold: 215 passing yards in Q2 at WAS in week 9.
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